James P Edwards Selected Research

1- (3- (4- (6- Chloro- 2,3- dihydro- 3- methyl- 2- oxo- 1H- benzimidazol- 1- yl)- 1- piperidinyl)propyl)- 4,5,6,7- tetrahydro- 5- (methylsulfonyl)- 3- (4- (trifluoromethyl)phenyl)- 1H- pyrazolo(4,3- c)pyridine

1/2004

Identification of a potent and selective noncovalent cathepsin S inhibitor.

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James P Edwards Research Topics

Disease

3	Inflammation (Inflammations) 01/2020 - 04/2004
2	Neoplasms (Cancer) 12/2021 - 09/2017
2	Rheumatoid Arthritis 01/2020 - 01/2017
2	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2018 - 01/2017
2	Agranulocytosis (Granulocytopenia) 01/2017 - 03/2014
2	Asthma (Bronchial Asthma) 01/2017 - 03/2014
2	Atopic Dermatitis (Atopic Eczema) 01/2017 - 03/2014
2	Peritonitis 06/2007 - 04/2004
1	Adenoma (Adenomas) 12/2021
1	Colorectal Neoplasms (Colorectal Cancer) 12/2021
1	Hyperalgesia 08/2020
1	Neuralgia (Stump Neuralgia) 08/2020
1	Peripheral Nerve Injuries 08/2020
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2020
1	Pruritus (Itching) 01/2017
1	Melanoma (Melanoma, Malignant) 03/2008
1	Otitis 06/2007
1	Edema (Dropsy) 06/2007
1	Atherosclerosis 05/2005
1	Arthritis (Polyarthritis) 05/2005
1	Chronic Obstructive Pulmonary Disease (COPD) 05/2005
1	Hypersensitivity (Allergy) 01/2004
1	Autoimmune Diseases (Autoimmune Disease) 01/2004

Drug/Important Bio-Agent (IBA)

2	CytokinesIBA 08/2020 - 01/2020
2	cathepsin SIBA 08/2020 - 05/2005
2	1- ((5- chloro- 1H- indol- 2- yl)carbonyl)- 4- methylpiperazineIBA 01/2017 - 04/2004
2	4- (3- aminopyrrolidin- 1- yl)- 6- isopropylpyrimidin- 2- ylamineIBA 01/2017 - 03/2014
2	Pharmaceutical PreparationsIBA 01/2017 - 03/2014
2	ZymosanIBA 06/2007 - 04/2004
1	Celecoxib (Celebrex)FDA Link 12/2021
1	Phosphotransferases (Kinase)IBA 12/2021
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 12/2021
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 12/2021
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 12/2021
1	Analgesics (Analgesic Drugs)IBA 08/2020
1	Immunoglobulin G (IgG)IBA 01/2020
1	Janus Kinase InhibitorsIBA 01/2020
1	CollagenIBA 01/2020
1	AcidsIBA 01/2018
1	Immune Checkpoint ProteinsIBA 09/2017
1	Biological ProductsIBA 09/2017
1	toreforantIBA 01/2017
1	Histamine (Histamine Dihydrochloride)FDA Link 03/2014
1	Mitogen-Activated Protein Kinase 3IBA 03/2008
1	Biomarkers (Surrogate Marker)IBA 03/2008
1	Interleukin-8 (Interleukin 8)IBA 03/2008
1	AgarIBA 03/2008
1	cysteinyl-leukotrieneIBA 06/2007
1	Arachidonic Acid (Vitamin F)IBA 06/2007
1	1- (4- (benzothiazol- 2- yloxy)benzyl)piperidine- 4- carboxylic acidIBA 06/2007
1	Carboxylic AcidsIBA 06/2007
1	LipoxinsIBA 06/2007
1	zileuton (Zyflo)FDA Link 06/2007
1	piperidineIBA 06/2007
1	1- (3- (4- (6- Chloro- 2,3- dihydro- 3- methyl- 2- oxo- 1H- benzimidazol- 1- yl)- 1- piperidinyl)propyl)- 4,5,6,7- tetrahydro- 5- (methylsulfonyl)- 3- (4- (trifluoromethyl)phenyl)- 1H- pyrazolo(4,3- c)pyridineIBA 01/2004

Therapy/Procedure

1	Chemoprevention 12/2021
1	Immunotherapy 09/2017